IMRT treatment planning for prostate cancer using prioritized prescription optimization and mean-tail-dose functions

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IMRT treatment planning for prostate cancer using prioritized prescription optimization and mean-tail-dose functions.

Treatment planning for intensity modulated radiation therapy (IMRT) is challenging due to both the size of the computational problems (thousands of variables and constraints) and the multi-objective, imprecise nature of the goals. We apply hierarchical programming to IMRT treatment planning. In this formulation, treatment planning goals/objectives are ordered in an absolute hierarchy, and the p...

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Radiation treatment planning for prostate cancer: A new dosimetric comparison of five and seven fields IMRT plans

Background: To compare the dosimetric coverage of the planning target volume (PTV) and the dose delivered to the main Organs at Risk (OARs) in 5 and 7-field techniques of Intensity Modulated Radiation Therapy (IMRT) in patients with local prostate cancer. Materials and Methods: Twelve patients with local prostate cancer underwent 5 and 7-field IMRT planning. The delivery of IMRT was carried out...

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Knowledge-based IMRT treatment planning for prostate cancer.

PURPOSE To demonstrate the feasibility of using a knowledge base of prior treatment plans to generate new prostate intensity modulated radiation therapy (IMRT) plans. Each new case would be matched against others in the knowledge base. Once the best match is identified, that clinically approved plan is used to generate the new plan. METHODS A database of 100 prostate IMRT treatment plans was ...

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Reduced-order parameter optimization for simplifying prostate IMRT planning.

Intensity-modulated radiotherapy (IMRT) has become an effective tool for cancer treatment with radiation. However, even expert radiation planners still need to spend a substantial amount of time manually adjusting IMRT optimization parameters such as dose limits and costlet weights in order to obtain a clinically acceptable plan. In this paper, we describe two main advances that simplify the pa...

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ژورنال

عنوان ژورنال: Linear Algebra and its Applications

سال: 2008

ISSN: 0024-3795

DOI: 10.1016/j.laa.2007.07.026